4/14/2021 0 Comments X Particles Infectio
Development of novel strategies to tackle antibiotic resistance is of the utmost priority.In this study, we combined glutathione (GSH), a master antioxidant in all mammalian cells, and nitric oxide, a proven biofilm-dispersing agent, to produce GSNO.
The resazurin biofilm viability assay, crystal violet biofilm assay, and confocal microscopy techniques showed that GSNO disrupted biofilms of both P. In addition, GSNO showed a higher reduction in biofilm viability and biomass when combined with antibiotics. A potentially inhalable GSNO powder with reasonable aerosol performance and antibiofilm activity was produced by spray drying. This combination shows promise as a novel formulation for treating pulmonary bacterial infections. The severity of bacterial infections depends largely on the type of bacteria involved. She specializes in pediatrics and disease and infection prevention. He is an attending emergency medicine physician at White Plains Hospital in White Plains, New York and also works at an urgent care center and a telemedicine company that provides care to patients across the country. ![]() Bacteria are small organisms that can invade the body, causing illness. These infections usually trigger a protective immune response. You also have innate bacteria in your body that helps digest your food and protect your body from harmful bacteria. Children and adults of any age can develop a bacterial infection. Bacteria can infect any area of the body, including the skin, bladder, lungs, intestines, brain, and more. A bacterial infection can also spread throughout the blood, causing a condition described as sepsis. You can experience generalized symptoms, such as fevers, chills, and fatigue as a result of a bacterial infection anywhere in the body. In addition to generalized symptoms, you can experience local effects of a bacterial infection, which correspond to the affected area or areas of the body. Pain, swelling, redness, and organ dysfunction are common localized symptoms. Pain is common with bacterial infections, and you can have skin pain with a bacterial skin infection, pain when breathing with a lung infection, and abdominal pain with an intestinal infection. You can easily identify redness or swelling on visible parts of the body, such as the skin, throat, or ears. Often, internal organs also become red and swollen when you have a bacterial infection, and while you cant see it, you may feel pain or other effects in these areas. For example, you may develop a productive cough, sometimes with thick mucus, with a bacterial infection of your respiratory tract (throat, bronchi, or lungs). And bacterial infections often cause diminished or altered function of the infected regions of the body. You may have impaired concentration with meningitis (an infection surrounding the brain) or decreased kidney function with pyelonephritis (a kidney infection). Different bacterial infections have a characteristic disease course. The symptoms can begin immediately or after a delay due to an incubation period. Bacterial infections are caused by the transmission of bacteria. You can be exposed to bacteria from other people, through the environment, or from eating contaminated food or drinking contaminated water. Anyone can become sick when exposed to bacteria, but having a weak immune system or taking immunosuppressive medication can make you more susceptible to developing a severe bacterial infectioneven from the bacteria that are normally innate to your body.
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